Wobenzym instructions for use in gastroenterology. Why is Wobenzym prescribed for kidney disease? Use in children

Wobenzym belongs to the category of medicines, the action of which is aimed at regulating the processes of tissue metabolism. It has enzymatic activity, thereby contributing to the removal of signs of inflammation and providing an immunomodulatory effect.

Wobenzym is available in the form of enteric-coated round tablets that can range in color from reddish-orange to red.

The active substance of Wobenzym tablets is a set of enzymes of plant and animal origin, supplemented with rutoside.

pharmachologic effect

The pharmacological effect achieved when taking Wobenzym tablets is primarily due to the cooperative mutually potentiating participation of various enzymes that make up the drug in the inflammatory and immune reactions of the body.

Each Wobenzym tablet contains pancreatin (100 mg), papain (60 mg), bromelain (45 mg), trypsin (24 mg), chymotrypsin (1 mg), amylase (10 mg), lipase (10 mg), rutin (50 mg), due to which a systemic anti-inflammatory and immunomodulatory effect is provided.

In addition, the use of Wobenzym enhances the therapeutic properties of antibiotics, increasing their concentration in the focus of inflammation, which is especially effective in the treatment of patients with latent infections. Also, the drug improves the penetration of antibacterial agents into microbial films, which are a community of microorganisms with a spatial and metabolic structure, located on the media interface and immersed in the extracellular polymer matrix.

Another important property of Wobenzym is its ability to reduce adverse reactions that may develop after taking medications. Taking pills prevents the development of intoxication and other conditions accompanied by a violation of the homeostasis of the internal environment of the body, as well as various kinds of functional disorders of the digestive system that occur during antibiotic treatment.

Pancreatin, which is part of Wobenzym, which is an extract of the contents of the pancreas of pigs and cattle, compensates for the insufficient activity of the body's own enzymes, normalizes digestive processes, promotes the breakdown of proteins into amino acids, fats - to glycerol and fatty acids, starch - to dextrins and monosaccharides, and also improves the functional state of the gastrointestinal tract. Among other things, the enzyme trypsin helps to suppress stimulated secretion of the pancreas and has an analgesic effect.

The proteolytic plant enzyme papain, which is obtained from the juice of the melon tree, catalyzes the hydrolysis of proteins, peptides, amides, and esters of basic amino acids.

Another proteolytic enzyme found in Wobenzym is bromelain, which is derived from pineapple fruit. Its action is aimed at improving digestive processes, removing signs of inflammation in injuries and swelling of injured soft tissues, as well as accelerating their recovery after certain injuries. Bromelain also prevents the formation of blood clots, and recent studies and reviews of Wobenzyme confirm its effectiveness in complementary therapy for cancerous tumors. In addition, bromelain is able to have an effect on the immune system, stimulating macrophage monocytes and cytotoxic T-lymphocytes, regulating the levels of cytokines and adhesive molecules, as well as eliminating pathogenic immune complexes from the blood and tissues that suppress the immune system.

Indications for the use of Wobenzym

In accordance with the instructions, Wobenzym is prescribed to adult patients as one of the components of complex therapy:

• In rheumatology - for the treatment of rheumatoid arthritis, extra-articular rheumatism, ankylosing spondylitis, Sjögren's syndrome, etc.;
• In angiology - for the treatment of diseases of the vessels of the circulatory and lymphatic systems: thrombophlebitis, vasculitis, phlebitis, lymphedema, post-thrombotic syndrome, etc.;
• In urology - to eliminate inflammatory diseases of the genitourinary system, cystitis, cystopyelitis, prostatitis, etc.;
• In surgical practice - for the treatment and prevention of the development of various kinds of postoperative complications, for the prevention of adhesions, the appearance of post-traumatic edema, etc.;
• In traumatology - with dislocations, fractures, bruises, sprains, chronic post-traumatic processes, sports injuries, etc.;
• In pulmonology - for the treatment of diseases affecting the upper and lower respiratory tract;
• In cardiology - for the treatment of coronary heart disease, as well as to mitigate the consequences of myocardial infarction;
• In gastroenterology - for the treatment of pancreatitis, ulcerative colitis, etc.;
• In nephrology - for the treatment of pyelonephritis and glomerulonephritis;
• In endocrinology - for the treatment of diabetic angiopathy, retinopathy, autoimmune thyroiditis, etc.;
• In dermatology - for patients with acne or atopic dermatitis;
• In neurology - with multiple sclerosis.

The use of Wobenzym is also justified, reviews confirm this:

• To prevent the development of infectious complications after surgery;
• To improve the general condition of the patient and improve the quality of his life during the passage of chemotherapy or radiation therapy for cancer;
• To prevent the development of viral infections;
• To restore the body after the stress it has suffered or the breakdown of adaptive mechanisms.

In addition, Wobenzym tablets prevent the occurrence of side effects from taking hormonal drugs, including contraceptives.

In the treatment of children, Wobenzym, according to reviews, is effective in atopic dermatitis, diseases of the respiratory system, juvenile rheumatoid arthritis, as a therapeutic and prophylactic agent in cases where surgical intervention is indicated for small patients.

Method of application and dosage

The optimal daily dose of the drug, as well as the duration of the course of treatment with Wobenzym, is determined based on the severity of the disease, the nature of its course, the age of the patient and his general state of health.

The drug is taken 3-10 tablets during the day, the frequency of receptions is 3. In the first three days of treatment, it is recommended to take Wobenzym three tablets three times a day.

Contraindications

Wobenzym's instruction prohibits the use of the drug:

• Patients who are at high risk of bleeding;
• During periods of hemodialysis;
• Children under the age of five;
• With increased sensitivity to the components of Wobenzym.

The drug is a whole complex of biologically active enzymes of animal and plant origin, which has pronounced immunomodulatory properties.

Wobenzym: composition and form of release

The drug is available in the form of tablets, which are coated with an orange enteric coating, with a shiny and smooth surface, with a characteristic odor.
The tablet contains:
- pancreatin - 100 mg;
- bromelain - 45 mg;
- papain - 60 mg;
- trypsin - 24 mg;
- amylase - 10 mg;
- chymotrypsin - 1 mg;
- rutin - 50 mg;
- lipase - 10 mg.
Among other things, the composition of the drug includes excipients: corn starch, lactose. stearic acid, magnesium stearate, water, talc, colloidal silicon dioxide, sucrose.
There are 20 tablets in a blister.

Wobenzym: properties

The drug has anti-inflammatory, antiaggregatory, fibrinolytic and secondary analgesic effects on the body. It has the following properties:
- stops the manifestation of autoimmune pathologies;
- enhances the functionality of macrophages;
- has a positive effect on the immunological activity of the body;
- stimulates the activity of T-lymphocytes and NK-cells (natural killers);
- stimulates phagocytic activity of cells and therefore antitumor immunity;
- reduces the number of circulating immune complexes;
- reduces infiltration of the interstitium by plasma cells;
- accelerates the breakdown of toxins;
- accelerates the resorption of edema and hematomas;
- improves the permeability of the walls of blood vessels, which in turn improves the removal of toxins from the body;
- regulates the adhesion of blood cells;
- normalizes the density and viscosity of the blood;
- improves blood microcirculation and its rheological properties;
- normalizes lipid metabolism;
- increases the content of high density lipoproteins;
- reduces the synthesis of endogenous cholesterol;
- increases the concentration of antibiotics in the focus of infectious processes;
- sharply reduces the negative consequences of taking hormonal drugs;
- regulates the production of interferons ...
This is not all, but the most basic properties of the drug.

Wobenzym: indications and contraindications

1. As part of complex and monotherapy, Wobenzym is used in the following cases:
- prostatitis, cystitis, cystopyelitis and other chronic and acute inflammations of the genitourinary system;
- thrombophlebitis, lymphatic edema, post-phlebitic syndrome, atherosclerosis of the leg arteries...;
- with genital infections;
- with mesopathy, preeclampsia, chronic infections;
- in post-infarction conditions (to improve the rheological properties of blood);
- with hepatitis and pancreatitis;
- in diseases of the lower and upper respiratory tract of an infectious nature (bronchitis, sinusitis, bronchial asthma, bronchopneumonia);
- with glomerulonephritis and pyelonephritis;
- with autoimmune thyroiditis;
- with multiple sclerosis;
- with acne and atopic dermatitis;
- with rheumatoid arthritis, ankylosing spondylitis and reactive arthritis;
- with diabetic retinopathy and diabetic angiopathy;
- with traumatic injuries of bones, soft tissues, joints, burns, injuries in sports medicine;
- in the treatment of various inflammatory processes in the postoperative period, adhesive disease, after reconstructive and plastic surgeries, with post-traumatic and lymphatic edema.
2. As a preventive agent, the drug is used:
- in case of microcirculation disorders, disruption of adaptation mechanisms and post-stress disorders;
- with viral infections and their complications;
- in cases of side effects of hormone replacement therapy;
- in cases of infectious complications and to improve the tolerability of radiation and chemotherapy;
- in order to prevent sapechny disease and other complications of an infectious nature.
3. For children, the drug is used in complex therapy for:
- juvenile rheumatoid arthritis;
- atopic dermatitis;
- chronic inflammatory diseases of the respiratory system in acute form;
- treatment and prevention of postoperative complications.

Wobenzym contraindications

Carrying out hemodialysis;
- age up to 5 years;
- diseases associated with poor blood clotting (thrombocytopenia, hemophilia);
- hypersensitivity to the components of the drug.

Equivalent replacement of Wobenzym without contraindications

Wobenzym: instructions for use

The drug is taken in doses from 3 to 10 tablets 3 times a day. In the first few days, it is recommended to take 3 tablets 3 times a day, then the dose is set depending on the severity of the disease and the individual characteristics of the organism.
With an average activity of the course of pathologies, Wobenzym is taken 7-10 tablets 3 times a day for 2-3 weeks. Then a prophylactic dose of 5 tablets 3 times a day for 2-3 months.
With long-term diseases that become chronic, it is advisable to stretch the course for 3-6 months.
In complex therapy, together with antibiotics, the drug should be taken throughout the entire antibiotic therapy course, 5 tablets 3 times a day. Then, to restore the microflora of the stomach, take 2-3 tablets 3 times a day for 2 weeks.
During the period of chemotherapy and radiation therapy, Wobenzym should be used 3 times a day, 3-5 tablets until the completion of the course of therapy.
For preventive purposes, the drug is also taken 3 times a day, 2-3 tablets for 1.5 months, with a course repeated up to 2-3 times a year.
Children over 12 years old are prescribed the adult dose, from 5 to 12 years old, 3-5 tablets 3 times a day.

Wobenzym tablets are taken 30 minutes before meals and washed down with a glass of water without chewing.

Side effects of Wobenzym

By and large, the drug is quite well tolerated by patients. But in some cases, there may be observed: diarrhea, nausea with vomiting, urticaria, changes in fecal cohesion. With the manifestation of all this, it is necessary to reduce the dose of the drug taken.
With extreme caution, it should be prescribed during pregnancy and in combination with drugs that reduce the properties of blood clotting.

Wobenzym: price and sale

This drug is very popular and therefore has a fairly wide distribution. It can be easily bought at almost any pharmacy, in any specialized department of the supermarket. But, Wobenzym, the price of which is almost the same everywhere, is often faked and therefore our advice to you: in no case do not buy the drug from your hands, from friends or in dubious establishments. Buy Wobenzym only from official companies that have a license for their activities and at the same time require a certificate of product conformity from the seller.
Well, what is its cost anyway? Wobenzym costs about 1,500 rubles for a pack of 200 tablets

Wobenzym, reviews of which are very diverse, but by and large - favorable, causes only one dissatisfaction - side effects. But for the sake of justice, it is worth saying that there are not so many patients suffering from this.

Wobenzym and Transfer Factor

(very important note)

The cost of Wobenzym is on average about 350 rubles. for 40 tablets, the course of therapy requires about 20-30 tablets per day, which must be taken for about 3 weeks, i.e. the cost of treatment with this drug will cost somewhere 3500-5000 rub., and the result is not guaranteed and requires repeated repetition.
Transfer factor performs exactly the same functions, in the package of which there are 90 capsules and its cost is about 2000 rub. Only TF has no contraindications and does not cause absolutely no side effects, an overdose of it is impossible and has no age restrictions. Among other things, its effect on our body is deeper and more radical - it puts in order the damaged human DNA, i.e. removes the cause of the disease, and does not deal with the treatment of its consequences.
But if you still decide to take Wobenzym, then we advise you to take it with TF in the complex, because. TF with such a complex intake neutralizes all its side effects and restores the microflora of the stomach, which is disturbed by Broncho munal, and this is one of the key links in our immunity.
you will read about the use of TF in various diseases.

Sometimes you can already understand its purpose by the name of the drug. A prime example is " Wobenzym", for which this remedy is prescribed, any connoisseur of Latin will say. But for the majority of the population, additional explanations will be needed, "dead" languages ​​are not taught very often.

Some types of diseases.

It should be understood that the mechanism of the development of the disease may lie both external and internal factor:

What is our immune system capable of?

Sometimes our immune system can take up arms against the tissues of our own body, the first signs:

• Disturbed recognition on the principle of "one's own or someone else's."
• Our body cells are perceived as foreign.
• Specialized lymphocytes are produced that attack the structures of their own body.
• Symptoms of an autoimmune disease appear.
• Without qualified help, the outcome can be tragic.

Pathology is not the most common and active attention was paid to its treatment only in the twentieth century. Prior to this, patients were doomed to a short and not very comfortable life.

However, even today it cannot be said that absolutely all violations of this kind are treated but medicine has taken a huge step forward. This is especially noticeable in pharmaceutical industry, what is one wobenzym worth.

In what situations is Wobenzym prescribed?

Tablets should be taken as directed by your doctor if you have such ailments:

1. Autoimmune thyroiditis.
2. Rheumatoid arthritis.
3. angina pectoris.
4. ischemic heart disease. (Cardiac ischemia)
5. Chronic inflammatory process in the lungs.
6. Chronic diseases of the gastrointestinal tract and urinary system are also treated with this drug, it quickly relieves inflammation and improves the general condition of the patient.

But the use of Wobenzym does not end there, it will find a place even in HPC due to its ability to relieve swelling. The medicine will not kill the bacteria that caused the venereal disease, but it will make life easier for the patient.

use the drug and ophthalmologists, also with inflammatory diseases, but already the eye.

To simplify a bit - Wobenzym can be applied anywhere inflammation can occur.

But what's the point of the name then? enzyme translates as ferment . But our enzymes have little to do with the elimination of inflammatory processes, they are designed to somewhat speed up the course of chemical reactions in the body. Increase their intensity, facilitate the launch of some processes. They have nothing to do with inflammatory, let alone autoimmune processes.

Appointment "Wobenzym" for digestive problems

The fact is that the composition of the drug includes enzymes of the human body. Basically, they stimulate the work of the gastrointestinal tract, somewhat simplifying the task of our stomach and intestines.

To start the process of absorption of nutrients, their preliminary grinding is necessary. This is done through mechanical and chemical processing:

1. Mechanics- the movement of the walls of the stomach and intestines, this is called peristalsis and is provided due to involuntary movements of the muscles. With age, the number of peristaltic movements decreases significantly, and patients begin to complain of constipation.
2. completeness chemical reactions, as you could already understand, provide the enzymes of our body. Some of them are produced directly in the stomach, but the main percentage falls on pancreas .

As a result of taking the drug, not only the load on the enzyme system of the body is reduced, but the process of digestion of food is also increased. Elementary physics and chemistry - small particles are absorbed and split much faster and with greater impact.

Why shouldn't you self-medicate?

Wobenzym also has an effect on the blood system. It stimulates blood flow in small vessels, by reducing the level of blood clots. Roughly speaking, the blood thins . This is another plus in terms of taking the drug. in old age.

But this effect also adds list of contraindications, because any impact on the blood system can lead to serious consequences.

In no case should you take drugs of this kind before surgical interventions. If the operating team is not notified in advance, they will have little chance of coping with the unstoppable bleeding.

Doctors like to prescribe vobzim because it is combined with many drugs enhancing their action. This must be taken into account when choosing a dose of the same antibiotics, so as not to cause too much damage to the body. The patient prefers this drug:

• For the speed of action. Within a couple of days, the patient will feel a sharp improvement.
• Restoration of lipid and protein metabolism.
• Reducing the level of symptoms.
• Removal of pain symptoms.

However, despite all these benefits, caution and prudence when prescribing this medicine, it will not be superfluous.

Having found a new entry and a few unfamiliar words in their medical record, everyone will immediately turn to the Internet for explanations. But what is Wobenzym, what is it prescribed for and what are its contraindications - all this should be explained by the attending physician.

Video about the appointment and use of "Wobenzym"

Instruction

Enzyme therapy is considered a new direction in medicine. One of the drugs based on a combination of enzymes of natural origin, acting systemically, is Wobenzym. It is included in therapeutic schemes for chronic and complicated diseases.

Latin name

Forms of release and composition

The drug is available only in the form of enteric tablets. This suggests that the components of the drug do not participate in the digestion process in the stomach, but dissolve in the small intestine, from the walls of which enzymes are actively distributed, bind to blood proteins and have a biological effect.

Round tablets of complex composition have a biconvex shape, covered with a smooth shell of red-orange color. Sold by 40, 100 or 200 pieces. (each blister contains 20 tablets), vials contain 800 tablets. Medicine packages (cardboard packs or polyethylene bottles) have a red and white design.

The substances that make up the dosage form are distributed as follows:

1. The active substances are concentrated in the nucleus. The volumes of enzymes are presented in units adopted by the Federation International Pharmaceutical, FIP / FIP. Each tablet contains:
   • 100 mg of pancreatin (300 proteolytic units) - necessary to compensate for the lack of enzymes and improve digestion;
   • 18 mg papain (90 FIP units) - inhibits the growth and reproduction of bacteria, improves immunity, has an antipyretic and analgesic effect;
   • 50 mg rutoside trihydrate (vitamin P) - prevents fragility and improves capillary permeability, improves blood flow;
   • 12 mg trypsin (360 FIP units) - provides an immunomodulatory effect, accelerates wound healing, prevents thrombosis, reduces edema (inflammatory and lymphatic);
   • 45 mg bromelain (225 FIP units) - improves immunity, removes toxic substances from the body, enhances the anti-inflammatory response, accelerates tissue repair and wound healing, reduces inflammatory and lymphatic edema;
   • 10 mg of lipase (34 FIP units) and amylase (50 FIP units) - both enzymes are necessary to improve metabolism, assimilation of vitamins;
   • 0.75 mg of chymotrypsin (300 FIP units) - is necessary to optimize the anti-inflammatory response, improve blood fluidity.
2. As excipients in the manufacture of the drug, lactose monohydrate, pregelatinized starch, stearic acid, magnesium stearate, anhydrous colloidal silicon dioxide, talc are used.
3. The composition of the film shell includes a copolymer of methacrylic acid and methyl methacrylate, sodium lauryl sulfate, triethyl citrate, macrogol 6000, talc, dyes, wax, clay, etc.

pharmachologic effect

Pharmacokinetics

A multicomponent medicine (7 enzymes and vitamin P) is a proportion of highly active enzymes of plant (papain, bromelain) and animal (pancreatin, trypsin, lipase, amylase, chymotrypsin) origin carefully selected in terms of quality and quantity. Systemic effects are realized through anti-inflammatory, immunomodulatory, antiplatelet, fibrinolytic, anti-edematous effects. Most of the enzymes also have a secondary analgesic property.

It has a positive effect on the indicators of the body's immunological reactivity, limits the pathological manifestations of autoimmune and immunocomplex processes, and stimulates antitumor immunity.

Under the influence of the medicinal composition, stimulation and regulation of the activity of monocytes-macrophages occurs, which absorb, neutralize and eliminate viruses and infected cells, cytotoxic T-lymphocytes responsible for the lysis of damaged cells.

Helps normalize lipid metabolism and reduce cholesterol synthesis. As a result of the action of the components of the tablets, the concentration of thromboxane decreases, the number of platelets normalizes, blood microcirculation improves, and the supply of tissues with oxygen.

The effectiveness of the therapeutic effect is improved due to the fact that the composition contains bromelain. This enzyme ensures the penetration and increase in the concentration of the antibiotic in the blood plasma and the focus of inflammation.

The drug reduces the severity of side effects that occur while taking antibiotics or hormonal agents.

The drug provides maximum recovery of the body, regulates the mechanisms for the production of interferons that provide antiviral immunity.

Indications for the use of Wobenzym

The list of diseases and pathological conditions in which an enzyme medication is included in the complex therapy is practically unlimited. It is prescribed for women and men:

• in urology in the treatment of chronic and acute diseases such as cystitis, prostatitis, STDs, urinary tract infections;
• in gynecology with endometriosis, adnexitis, mastopathy, uterine myoma, gestosis, genital infections;
• in angiology in the treatment of thrombophlebitis (including acute thrombophlebitis), obliterating endarteritis, postphlebitic syndrome, atherosclerosis of the leg arteries, lymphatic edema, thrombosis and other arterial lesions;
• in gastroenterology (hepatitis, pancreatitis);
• in cardiology - to improve the rheological properties of blood, which is important for patients with myocardial infarction, angina pectoris;
• in nephrology for patients with pyelonephritis or glomerulonephritis;
• in rheumatology (arthritis, ankylosing spondylitis, etc.);
• in pulmonology (pneumonia, bronchitis, sinusitis);
• in endocrinology (thyroiditis, diabetic retinopathy and angiopathy);
• in dermatology;
• in surgery (including plastic) to prevent postoperative complications;
• in traumatology (burns, injuries, bruises, hematomas, etc.);
• in pediatrics for any infectious and inflammatory processes;
• in ophthalmology (including ophthalmic surgery).

In most areas of medicine, the drug is prescribed for prevention purposes, because. the combination of enzymes has a beneficial effect on the immune system and helps to avoid infectious complications after surgery, chemotherapy and radiation therapy for oncology, adhesive disease.

As a prophylactic, it is used for recurrent phlebitis, viral infections of the respiratory tract. Helps to reduce side effects if the patient is prescribed a course of hormone replacement therapy.

Contraindications

As part of the tablets, enzymes are only of natural origin, so there are few contraindications, but they are. Patients cannot use the medication:

• having diseases with a high probability of developing bleeding (for example, hemophilia or thrombocytopenia);
• undergoing hemodialysis;
• having individual intolerance to any component;
• under 5 years old.

How to take Wobenzym

To include the drug in the treatment course, it is necessary to take into account the type and severity of the disease, therefore, only the attending physician should prescribe dosages and duration of administration. Preventive courses are also signed by the doctor according to indications and taking into account the patient's condition.

Pills

The duration of the course can be from 2 weeks to several months, which is explained by the characteristics of the absorption of components from the small intestine. Every day, the patient should drink from 9 to 15 tablets (this recommendation is average, the doctor may increase the dosage in accordance with the indications). The number of tablets is divided into 3 doses. Tablets are swallowed whole, without chewing, washed down with a glass of water.

Before or after meals

For urological diseases

Enzyme therapy is prescribed by urologists for most diseases of the urogenital area and is considered an indispensable part of complex treatment. It can be chronic and acute pathologies, infectious and bacterial. Systemic enzyme therapy helps to point concentrate antibiotics in the foci of inflammation, reduce intoxication in organs and tissues.

With prostatitis, enzymes help reduce pain, prevent its spread, and have a positive effect on sexual function.

With cystitis, enzymes accelerate recovery, prevent relapses and the transition of the disease to a chronic form.

The course can be from 3 to 6 months with a daily 3-fold intake of 3-5 tablets.

With mastopathy

The course of treatment should be comprehensive. The gynecologist prescribes, among other things, the described drug, which in the course of research has shown not only the ability to eliminate the symptoms of the disease, but also the effect on its cause. With prolonged use (at least 3 months, 15 tablets per day), the drug can prevent the growth of cysts, pathological neoplasms in the tissues of the mammary gland.

With pancreatitis

Side effects of taking Wobenzym

Most patients tolerate long-term enzyme therapy well, without side effects, addiction or withdrawal. Only in some cases, as a result of taking the tablets, changes in fecal masses (consistency, smell) were noted.

Children over 5 years of age are prescribed a daily dose at the rate of 1 tablet for every 6 kg of body weight. If the child is over 12 years old, then adult dosages are used when prescribing the drug.

Influence on concentration

It does not have a negative effect on the activity associated with the manifestation of psychomotor reactions, and is not doping.

drug interaction

With other drugs

Cases of incompatibility with other drugs have not been recorded. Increases the effectiveness of antibacterial drugs of the main groups:

• penicillins (including semi-synthetic);
• cephalosporins;
• aminoglycosides;
• lincosamides;
• macrolides;
• tetracyclines;
• fluoroquinolones.

Alcohol compatibility

Any treatment course loses its meaning if the patient consumes alcohol at the same time, because. ethanol reduces the effectiveness of drugs. In addition, enzymes are prescribed as an addition to complex treatment, so alcohol may be contraindicated in combination with other drugs.

Terms and conditions of storage

Tablets are assigned to list B, which implies storage in a dry place at + 15 ... + 25 ° С. Access of children to the place of storage of the medicine should be excluded. It is allowed to use the drug for 30 months if the storage conditions have been met.

Terms of dispensing from pharmacies

Are they sold without a prescription?

Non-prescription medication.

Price

Depends on the number of tablets. Minimum prices: for 40 pcs. - 411 rubles, for 800 pcs. — 5800 rub.

Analogues

It is not so easy to find cheap Russian drugs that can replace the German enzyme complex. Other drugs do not have the same wide range of indications.

A doctor who is familiar with the patient's medical history will help you choose a complete replacement for the content of enzymes or immunomodulatory properties.

Wobenzym is a highly effective drug. It is a complex of highly active animal and plant enzymes (enzymes).

It combines in its composition enzymes of animal and vegetable origin with the addition of rutoside. It has an immunomodulatory and anti-inflammatory effect, affects reparative processes. They are widely used in various branches of medicine and are used to improve the body as part of the complex treatment of various diseases.

On this page you will find all the information about Wobenzym: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Wobenzym. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

A drug with anti-inflammatory and immunomodulatory effects.

Terms of dispensing from pharmacies

Released without a doctor's prescription.

Prices

How much does Wobenzym cost? The average price in pharmacies is at the level of 480 rubles.

Release form and composition

Round biconvex tablets with a smooth surface, without cracks, with a characteristic light vanilla odor, orange-red in color. Fluctuations in the color intensity of the outer shell from orange-red to red are allowed.

• Active substances: Pancreatin 345 prot. – Europe. Pharm. - U, papain - 90 FIP-U, rutoside ZH2O 50.00 mg, bromelain 225 FIP-U, trypsin 360 FIP-U, lipase 34 FIP-U, amylase 50 FIP-U, chymotrypsin 300 FIP -Unit

Excipients: Lactose, corn starch, magnesium stearate, stearic acid, purified water, colloidal silicon dioxide, talc. Sucrose, talc, calcium carbonate, copolymer of metaacrylic acid - methyl methacrylate, shellac, titanium dioxide, white clay, yellow-orange dye S (E 13 0), crimson dye 4 R (E 124), povidone, macrogol 6000, triethyl citrate, vanillin, bleached wax, carnauba wax.

Pharmacological effect

Wobenzym is a combination of highly active enzymes of plant and animal origin with immunomodulatory, anti-inflammatory, anti-edematous, fibrinolytic and secondary analgesic effects.

Enzymes (enzymes) are the basis of the body's vital activity and take part in almost all biological processes of the body. Decreased enzyme activity often leads to acute and chronic diseases. Wobenzym has a positive effect on the course of the inflammatory process, limits the pathological manifestation of autoimmune and immunocomplex processes, and has a positive effect on the parameters of the body's immunological reactivity. It stimulates and regulates the level of functional activity of monocytes-macrophages, natural killer cells, stimulates antitumor immunity, cytotoxic T-lymphocytes, phagocytic activity of cells.

Under the influence of Wobenzym, the number of circulating immune complexes decreases and the membrane deposits of immune complexes are removed from tissues. Wobenzym accelerates the lysis of toxic metabolic products and necrotic tissues. Improves resorption of hematomas and edema, normalizes the permeability of vessel walls. Normalizes blood viscosity and microcirculation. Improves the supply of tissues with oxygen and nutrients. Wobenzym reduces the concentration of thromboxane and platelet aggregation. Regulates the adhesion of blood cells, increases the ability of erythrocytes to change their shape by regulating their plasticity, normalizes the number of normal discocytes and reduces the total number of activated forms of platelets, normalizes blood viscosity, reduces the total number of microaggregates, thus improving microcirculation and rheological properties of blood, as well as tissue supply oxygen and nutrients. Wobenzym reduces the side effects associated with taking hormonal drugs.

The secondary analgesic effect of Wobenzym is manifested through the impact on the causative factors of an acute inflammatory process. Wobenzym normalizes lipid metabolism, reduces the synthesis of endogenous cholesterol, increases the content of high-density lipoproteins, reduces the level of atherogenic lipids, and improves the absorption of polyunsaturated fatty acids. Wobenzym increases the concentration of antibiotics in the blood plasma and inflammation, thus increasing the effectiveness of their use. At the same time, enzymes reduce unwanted side effects of antibiotic therapy. Wobenzym regulates the mechanisms of nonspecific protection (production of interferons), thereby exhibiting antiviral and antimicrobial effects.

Indications for use

As part of complex treatment, indications for the use of Wobenzym are:

1. , ankylosing spondylitis;
2. Multiple sclerosis;
3. Acne, ;
4. Iridocyclitis, uveitis, hemophthalmia;
5. , and cystopyelitis;
6. Glomerulonephritis, ;
7. Diabetic retinopathy and angiopathy;
8. , postphlebitic syndrome, atherosclerosis of the arteries of the lower extremities and obliterating endarteritis, lymphedema;
9. Infections that are sexually transmitted;
10. Chronic infections of the genitals, mastopathy, gestosis;
11. stress and subacute stage;
12. Bruises, injuries, fractures, damage to the ligamentous apparatus, chronic post-traumatic processes, burns, inflammation of soft tissues;
13. Postoperative complications, reconstructive and plastic surgery.

It is also recommended to prescribe for the prevention of post-stress disorders, disruption of adaptive mechanisms, microcirculation disorders, side effects of hormonal contraception, adhesive disease and infectious complications during surgical interventions, as well as during radiation or chemotherapy.

Contraindications

Wobenzym is generally well tolerated, but there are several contraindications:

• blood diseases with a risk for the development of bleeding;
• renal failure, hemodialysis procedures;
• age up to 5 years;
• hypersensitivity to the composition of the drug.

Use during pregnancy and lactation

Perhaps the appointment of the drug during pregnancy and lactation. Reception is carried out under strict medical supervision.

Instructions for use

The instructions for use indicate that the dosage of Wobenzym is set individually, depending on the severity of the disease. The drug should be taken at least 30 minutes before meals, without chewing, with water (200 ml).

Adults, depending on the activity and severity of the disease, are prescribed in a dose of 3 to 10 tablets. 3 times / day. In the first 3 days of taking the drug, the recommended dose is 3 tab. 3 times / day.

1. With an average activity of the disease, the drug is prescribed in a dose of 5-7 tab. 3 times / day for 2 weeks. In the future, the dose of the drug should be reduced to 3-5 tab. 3 times / day. Course - 2 weeks.
2. With high disease activity, the drug is prescribed in a dose of 7-10 tab. 3 times / day for 2-3 weeks. In the future, the dose should be reduced to 5 tab. 3 times / day. Course - 2-3 months.
3. In chronic long-term diseases, Wobenzym can be used according to indications in courses of 3 to 6 months or more.

In order to increase the effectiveness of antibiotics and prevent dysbacteriosis, Wobenzym should be used throughout the course of antibiotic therapy at a dose of 5 tab. 3 times / day. After stopping the course of antibiotic therapy to restore the intestinal microflora, Wobenzym should be prescribed 3 tab. 3 times / day for 2 weeks.

During radiation and chemotherapy, Wobenzym should be used at a dose of 5 tab. 3 times / day until the completion of the course of radiation and chemotherapy in order to prevent infectious complications, improve the tolerability of basic therapy and improve the quality of life.

For prophylactic purposes, Wobenzym is prescribed 3 tab. 3 times / day for 1.5 months with a repetition of the course 2-3 times a year.

Children aged 5-12 years are prescribed in a daily dose at the rate of 1 tab. per 6 kg of body weight. For children over 12 years of age, the drug is prescribed according to the scheme intended for adults. The duration of treatment is determined individually.

Side effects

The drug is well tolerated, only in some cases it is noted: digestive system disorders, nausea, allergic reactions. After feeling discomfort after taking the drug, it is recommended to consult a doctor. Before taking the drug, you need to consult a doctor. Do not self-medicate, which can be harmful to health or provoke complications.

Overdose

In medicine, there have been no cases of overdose with Wobenzym tablets, even with prolonged use, however, in order to prevent the development of side effects, the dosage indicated by the doctor should not be exceeded.

special instructions

1. At the very beginning of taking the drug, the symptoms of the disease may worsen, in such cases, treatment should not be interrupted, and a temporary reduction in the dose of the drug is recommended.
2. In the case of infectious processes, Wobenzym does not replace antibiotics, but increases their effectiveness by increasing the concentration in the blood plasma and inflammation.
3. The drug is not doping and does not adversely affect the ability to drive vehicles and perform work that requires a high rate of mental and physical reactions.

drug interaction

Wobenzym tablets can be taken simultaneously with other drugs, as the enzymes that make up the drug enhance the therapeutic effect of drugs and at the same time reduce the risk of side effects.

It is important to understand that this drug does not replace antibiotics or other drugs for diseases, but only enhances their therapeutic effect.